Lead in PDB 4xjn: Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity

The structure of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity, PDB code: 4xjn was solved by M.Alayyoubi, G.P.Leser, C.A.Kors, R.A.Lamb, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.01 / 3.11
Space group	C 2 2 21 1
Cell size a, b, c (Å), α, β, γ (°)	205.636, 309.436, 233.241, 90.00, 90.00, 90.00
R / Rfree (%)	22.7 / 26.3

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 14;

Binding sites:

The binding sites of Lead atom in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity (pdb code 4xjn). This binding sites where shown within 5.0 Angstroms radius around Lead atom.
In total 14 binding sites of Lead where determined in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity, PDB code: 4xjn:
Jump to Lead binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Lead binding site 1 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 1 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ A:Pb601 b:70.8 occ:0.32 O2' N:U11 3.6 45.4 1.0 SG A:CYS181 4.1 75.2 1.0 SG A:CYS264 4.1 56.1 1.0 SG A:CYS179 4.1 69.1 1.0 O A:CYS179 4.3 46.0 1.0 C A:CYS179 4.4 45.9 1.0 N A:CYS181 4.4 63.6 1.0 C A:LYS180 4.4 59.1 1.0 N A:LYS180 4.6 45.0 1.0 CA A:CYS181 4.6 65.3 1.0 O A:LYS180 4.7 55.6 1.0 CA A:LYS180 4.8 47.9 1.0 C2' N:U11 4.9 43.2 1.0 CA A:CYS179 4.9 43.9 1.0 CB A:ALA314 5.0 32.3 1.0

Lead binding site 2 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 2 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ B:Pb601 b:0.1 occ:1.00 OE2 B:GLU103 3.0 35.1 0.0 OE1 B:GLU103 3.0 35.3 0.0 CD B:GLU103 3.4 34.6 0.0 CB B:ARG101 4.1 32.4 1.0 NH1 B:ARG119 4.2 31.1 1.0 N B:VAL102 4.3 31.2 1.0 OE2 B:GLU100 4.4 40.5 0.0 N B:ARG101 4.6 27.6 1.0 CA B:ARG101 4.7 29.8 1.0 C B:ARG101 4.8 30.0 1.0 CG B:ARG101 4.8 30.9 1.0 CD B:GLU100 4.9 36.6 0.0 CD B:ARG119 4.9 30.9 1.0 CG B:GLU103 4.9 33.4 0.0

Lead binding site 3 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 3 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ D:Pb601 b:82.6 occ:0.33 OE2 D:GLU390 2.5 91.7 1.0 CD D:GLU390 3.1 90.5 1.0 OE1 D:GLU390 3.1 89.0 1.0 O D:GLY385 3.3 71.6 1.0 NH1 I:ARG391 3.6 1.0 1.0 SD I:MET378 3.8 67.2 1.0 CE I:MET378 3.9 72.2 1.0 CG2 D:THR387 4.1 0.6 1.0 NH2 I:ARG391 4.2 98.7 1.0 C D:GLY385 4.3 67.7 1.0 CZ I:ARG391 4.4 0.8 1.0 CG I:MET378 4.4 63.9 1.0 N D:THR387 4.4 99.8 1.0 CG D:GLU390 4.5 0.3 1.0 CA D:LEU386 4.5 78.6 1.0 OG1 D:THR387 4.7 0.3 1.0 C D:LEU386 4.8 87.4 1.0 N D:LEU386 4.8 72.2 1.0 O D:LEU384 4.9 77.8 1.0 CB D:THR387 5.0 0.7 1.0

Lead binding site 4 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 4 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ G:Pb601 b:0.1 occ:1.00 OE2 G:GLU103 3.7 33.3 0.0 NH1 G:ARG119 3.9 28.3 1.0 CB G:ARG101 4.1 31.0 1.0 CG G:GLU103 4.3 34.2 0.0 CD G:GLU103 4.3 32.7 0.0 N G:VAL102 4.3 28.9 1.0 N G:ARG101 4.6 27.9 1.0 CA G:ARG101 4.7 28.2 1.0 OE2 G:GLU100 4.7 40.4 0.0 C G:ARG101 4.8 31.2 1.0 CG G:ARG101 4.8 27.8 1.0 OG G:SER120 4.9 51.4 1.0

Lead binding site 5 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 5 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ H:Pb601 b:59.4 occ:0.37 O2' N:U47 3.8 46.3 1.0 SG H:CYS179 4.2 65.0 1.0 SG H:CYS264 4.2 49.5 1.0 CB H:ALA314 4.7 27.8 1.0 CB H:CYS181 4.7 65.5 1.0 O H:CYS179 4.8 49.2 1.0 N H:CYS181 4.9 63.5 1.0 C1' N:U47 4.9 45.8 1.0 CA H:CYS181 4.9 67.9 1.0 C2' N:U47 4.9 45.4 1.0 C H:CYS179 5.0 47.6 1.0 CA H:GLY265 5.0 32.6 1.0

Lead binding site 6 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 6 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ I:Pb601 b:94.6 occ:1.00 OE2 I:GLU103 2.9 38.6 0.0 OE1 I:GLU103 3.0 37.6 0.0 CD I:GLU103 3.3 37.3 0.0 NH1 I:ARG119 4.1 32.0 1.0 PB I:PB602 4.1 94.9 1.0 CB I:ARG101 4.2 30.5 1.0 N I:VAL102 4.3 28.0 1.0 N I:ARG101 4.6 30.8 1.0 OE2 I:GLU100 4.6 41.5 0.0 CD I:ARG119 4.7 31.8 1.0 CA I:ARG101 4.7 28.9 1.0 C I:ARG101 4.8 29.7 1.0 CG I:ARG101 4.8 32.2 1.0 CG I:GLU103 4.9 35.2 0.0 CD I:GLU100 5.0 38.9 0.0

Lead binding site 7 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 7 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ I:Pb602 b:94.9 occ:1.00 OE2 I:GLU100 2.0 41.5 0.0 OE1 I:GLU100 2.3 35.6 0.0 CD I:GLU100 2.4 38.9 0.0 CG I:GLU100 3.8 34.1 0.0 PB I:PB601 4.1 94.6 1.0 CB I:GLU100 4.7 31.9 0.0

Lead binding site 8 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 8 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ K:Pb601 b:57.0 occ:1.00 OE2 K:GLU103 2.9 33.7 0.0 OE1 K:GLU103 3.0 33.8 0.0 CD K:GLU103 3.4 33.6 0.0 PB K:PB602 4.1 62.1 1.0 NH1 K:ARG119 4.1 35.0 1.0 CB K:ARG101 4.2 32.0 1.0 N K:VAL102 4.3 29.6 1.0 OE2 K:GLU100 4.4 42.5 0.0 N K:ARG101 4.6 31.2 1.0 CA K:ARG101 4.7 30.6 1.0 C K:ARG101 4.8 32.4 1.0 CD K:GLU100 4.8 40.3 0.0 CG K:GLU103 4.9 32.9 0.0 CG K:ARG101 4.9 30.7 1.0

Lead binding site 9 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 9 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ K:Pb602 b:62.1 occ:1.00 OE2 K:GLU100 2.1 42.5 0.0 OE1 K:GLU100 2.2 37.8 0.0 CD K:GLU100 2.4 40.3 0.0 CG K:GLU100 3.9 35.5 0.0 PB K:PB601 4.1 57.0 1.0 CB K:GLU100 4.8 33.2 0.0

Lead binding site 10 out of 14 in the Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 10 of Structure of the Parainfluenza Virus 5 Nucleocapsid-Rna Complex: An Insight Into Paramyxovirus Polymerase Activity within 5.0Å range: probe atom residue distance (Å) B Occ M:Pb601 b:83.5 occ:1.00 OE2 M:GLU103 3.1 35.8 0.0 OE1 M:GLU103 3.1 35.6 0.0 CD M:GLU103 3.5 35.1 0.0 PB M:PB602 4.0 0.3 1.0 OE2 M:GLU100 4.1 37.7 0.0 CB M:ARG101 4.1 33.8 1.0 NH1 M:ARG119 4.1 27.8 1.0 N M:VAL102 4.2 31.5 1.0 N M:ARG101 4.6 30.9 1.0 OE1 M:GLU100 4.6 39.1 0.0 CA M:ARG101 4.7 30.4 1.0 CD M:GLU100 4.7 37.9 0.0 C M:ARG101 4.8 31.6 1.0 CG M:ARG101 4.8 32.1 1.0 CD M:ARG119 4.8 33.7 1.0 CG M:GLU103 5.0 34.9 0.0

M.Alayyoubi, G.P.Leser, C.A.Kors, R.A.Lamb. Structure of the Paramyxovirus Parainfluenza Virus 5 Nucleoprotein-Rna Complex To Be Published.