Lead in PDB 1zhy: Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol

The structure of Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol, PDB code: 1zhy was solved by Y.J.Im, S.Raychaudhuri, W.A.Prinz, J.H.Hurley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.62 / 1.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	82.760, 94.210, 65.412, 90.00, 96.27, 90.00
R / Rfree (%)	21.6 / 23.2

The binding sites of Lead atom in the Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol (pdb code 1zhy). This binding sites where shown within 5.0 Angstroms radius around Lead atom.
In total 2 binding sites of Lead where determined in the Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol, PDB code: 1zhy:
Jump to Lead binding site number: 1; 2;

Lead binding site 1 out of 2 in the Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 1 of Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol within 5.0Å range: probe atom residue distance (Å) B Occ A:Pb2001 b:32.8 occ:1.00 OE2 A:GLU204 2.6 41.6 1.0 OE1 A:GLU204 2.8 40.6 1.0 O A:ARG236 2.8 32.5 1.0 CD A:GLU204 3.1 39.4 1.0 C A:ARG236 3.7 32.2 1.0 CA A:GLY237 4.1 30.2 1.0 O A:HOH2261 4.2 36.0 1.0 N A:GLY237 4.2 30.6 1.0 NE2 A:HIS202 4.4 26.8 1.0 CB A:ARG236 4.5 35.8 1.0 CG A:GLU204 4.6 35.0 1.0 CA A:ARG236 4.7 32.6 1.0 CE1 A:TYR238 4.8 36.1 1.0 CD1 A:TYR238 4.8 35.0 1.0 CG A:GLU214 4.9 32.9 1.0

Lead binding site 2 out of 2 in the Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 2 of Structure of Yeast Oxysterol Binding Protein OSH4 in Complex with Cholesterol within 5.0Å range: probe atom residue distance (Å) B Occ A:Pb2002 b:39.5 occ:1.00 OD1 A:ASP364 2.7 32.8 1.0 OD2 A:ASP364 2.7 30.3 1.0 CG A:ASP364 3.1 30.9 1.0 O A:HOH2135 4.1 31.0 1.0 CB A:ASP364 4.6 27.4 1.0 OE2 A:GLU372 4.7 44.5 1.0 O A:HOH2253 4.8 36.9 1.0 O A:ASP364 4.9 29.7 1.0

Y.J.Im, S.Raychaudhuri, W.A.Prinz, J.H.Hurley. Structural Mechanism For Sterol Sensing and Transport By Osbp-Related Proteins Nature V. 437 154 2005.
ISSN: ISSN 0028-0836
PubMed: 16136145
DOI: 10.1038/NATURE03923