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Lead in PDB 1efn: Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain

Enzymatic activity of Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain

All present enzymatic activity of Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain:
2.7.1.112;

Protein crystallography data

The structure of Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain, PDB code: 1efn was solved by C.-H.Lee, J.Kuriyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 6.00 / 2.50
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 107.800, 107.800, 229.100, 90.00, 90.00, 120.00
R / Rfree (%) 21.5 / 28.2

Lead Binding Sites:

The binding sites of Lead atom in the Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain (pdb code 1efn). This binding sites where shown within 5.0 Angstroms radius around Lead atom.
In total 2 binding sites of Lead where determined in the Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain, PDB code: 1efn:
Jump to Lead binding site number: 1; 2;

Lead binding site 1 out of 2 in 1efn

Go back to Lead Binding Sites List in 1efn
Lead binding site 1 out of 2 in the Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 1 of Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pb710

b:50.4
occ:1.00
PB B:PBM710 0.0 50.4 1.0
C2 B:PBM710 2.1 41.2 1.0
C3 B:PBM710 2.1 42.2 1.0
C1 B:PBM710 2.1 45.5 1.0
NE2 B:HIS192 3.0 30.6 1.0
CD2 B:HIS192 3.5 27.9 1.0
CE1 B:HIS192 4.1 31.6 1.0
O B:HOH870 4.5 37.8 1.0
CB B:PHE191 4.6 12.6 1.0
CG B:HIS192 4.8 29.5 1.0

Lead binding site 2 out of 2 in 1efn

Go back to Lead Binding Sites List in 1efn
Lead binding site 2 out of 2 in the Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain


Mono view


Stereo pair view

A full contact list of Lead with other atoms in the Pb binding site number 2 of Hiv-1 Nef Protein in Complex with R96I Mutant Fyn SH3 Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Pb720

b:60.2
occ:0.70
PB D:PBM720 0.0 60.2 0.7
C1 D:PBM720 2.1 58.9 0.7
C2 D:PBM720 2.1 60.1 0.7
C3 D:PBM720 2.1 58.2 0.7
O B:HOH842 3.9 20.9 1.0
O D:HOH891 3.9 50.3 1.0
O D:PRO122 4.1 16.1 1.0
O B:PRO122 4.2 27.9 1.0
CG D:PRO122 4.7 11.7 1.0
OD1 B:ASP108 4.7 31.3 1.0
CB D:PRO122 4.7 10.4 1.0
CB B:PRO122 4.8 19.6 1.0
O D:HOH818 4.9 39.6 1.0
CG B:PRO122 4.9 18.0 1.0
OD1 D:ASP108 4.9 36.4 1.0

Reference:

C.H.Lee, K.Saksela, U.A.Mirza, B.T.Chait, J.Kuriyan. Crystal Structure of the Conserved Core of Hiv-1 Nef Complexed with A Src Family SH3 Domain. Cell(Cambridge,Mass.) V. 85 931 1996.
ISSN: ISSN 0092-8674
PubMed: 8681387
DOI: 10.1016/S0092-8674(00)81276-3
Page generated: Wed Dec 16 02:01:56 2020

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